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DiscoveryProbe™ Stem Cell-related Compounds Panel

DiscoveryProbe™ Stem Cell-related Compounds Panel

产品编号:L1017
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Sample solution is provided at 25 µL, 10mM.

Click and Customize the Panel with your own choices of compounds/size/qtuanties/chemical forms etc.

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Related Biological Data

KY 02111
KY 02111 inhibits canonical Wnt pathway

Related Biological Data

KY 02111
KY 02111 inhibits canonical Wnt pathway

Related Biological Data

Cyclopamine

Related Biological Data

Cyclopamine

Signaling Pathway

Wnt/β-catenin Research Area
Wnt/β-catenin Compare Products
Hedgehog Compare Products
GSK-3 Compare Products

Compound Panel Contents

Catalog No. Product Name Summary Targets CAS Number Smiles
A3446 GSK126 EZH2 inhibitor Stem Cell|EZH2 1346574-57-9 CCC(C)N1C=C(C2=C(C=C(C=C21)C3=CN=C(C=C3)N4CCNCC4)C(=O)NCC5=C(C=C(NC5=O)C)C)C
A8500 PF-5274857 Smo antagonist,potent and selective Stem Cell|Hedgehog 1373615-35-0 CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CCS(=O)(=O)C)C
A8950 UM 171 HSC agonist Stem Cell|HSC 1448724-09-1 N[C@@H](CC1)CC[C@H]1NC2=NC(CC3=CC=CC=C3)=NC(N4)=C2C5=C4C=C(C6=NN(C)N=N6)C=C5
A8685 Wnt-C59 PORCN inhibitor,highly potent and selective Stem Cell|Wnt/β-catenin 1243243-89-1 CC1=NC=CC(=C1)C2=CC=C(C=C2)CC(=O)NC3=CC=C(C=C3)C4=CN=CC=C4
A2149 Bosutinib (SKI-606) Potent Abl/Src kinases TGF-β / Smad Signaling|Bcr-Abl 380843-75-4 CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
A8330 CX-4945 (Silmitasertib) CK2 inhibitor TGF-β / Smad Signaling|PKC 1009820-21-6 C1=CC(=CC(=C1)Cl)NC2=C3C=CN=CC3=C4C=CC(=CC4=N2)C(=O)O
Download the Stem Cell-related Compounds Panel - XLSX       Download the Stem Cell-related Compounds Panel - SDF

Advantages

  • Available in stock with overnight delivery and free shipping over $500
  • Cost-effective and competitive price to save your findings
  • Potent, selective and cell-permeable in inhibiting or activating target molecules
  • Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
  • Detailed files describing potency, selectivity and applications etc.
  • Supported by published data from top peer-reviewed journals
  • Guaranteed high quality with NMR and HPLC validation

产品描述

A wide range of well-characterized bioactive molecules that covers various targets related to stem cell, including hedgehog, smoothened and Wnt/β-catenin etc. Facilitate your research towards the insights of cell proliferation, growth and differentiation etc. Applicable in cellular assays, animal models and drug screenings etc.

References

1. Clevers H, Loh KM, Nusse R. Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Science. 2014 Oct 3;346(6205):1248012
Abstract
Wnt signals emanating from the the local stem cell microenvironment can act as self-renewal factors for stem cells in multiple mammalian tissues. In this Review, we discuss the various ways by which Wnt operates in stem cell control and, in doing so, identify an integral program for tissue renewal and regeneration.