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ML-099Ras相关GTPase的激活剂

ML-099

产品编号:C4771
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Sample solution is provided at 25 µL, 10mM.

质量控制

质量控制和MSDS

批次:

化学结构

ML-099

ML-099 Dilution Calculator

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ML-099 Molarity Calculator

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化学性质

CAS号 496775-95-2 SDF Download SDF
别名 CID-888706
化学名 2-[(2-phenylethyl)thio]-3-pyridinecarboxylic acid
SMILES OC(C1=CC=CN=C1SCCC2=CC=CC=C2)=O
分子式 C14H13NO2S 分子量 259.3
溶解度 ≤10mg/ml in DMSO 储存条件 Store at -20°C
物理性状 A crystalline solid 运输条件 试用装:蓝冰运输。
其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议 为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

产品描述

ML-099 is a small molecule pan activator of Ras-related GTPases.

The Ras-related GTPases contain over 50 members, including the Arf, Rho, Ras, and Rab GTPase subfamilies. The Ras-related GTPases behave as molecular switches with an active form (GTP-bound) and an inactive form (GDP-bound) conformation. It has been reported that the Ras-related GTPases have been involved in regulating a variety of cellular processes ranging from membrane trafficking to the control of cell proliferation. Abberant mutations in the small guanosinetriphosphatases (GTPases) may result in disease either through aberrant activation or through loss of function or diminished acitivity [1].

ML-099 activated Rac1, cell division cycle 42 activated mutant, cell division cycle 42, Ras protein (WT) , Rab-2A, GTP-binding protein with the EC50 values of 20, 58.8, 100, 141, and 355, and 181.97 nM, respectively [1].

Reference:
[1] Surviladze Z, Ursu O, Miscioscia F, et al.  Three small molecule pan activator families of Ras-related GTPases[J]. 2010.